Oxidised LDL Cholesterol (Ox-LDL-C) and Ox-LDL-C/HDL Cholesterol (HDL-C) Ratio in Acute Coronary Syndrome Patients versus Chronic Coronary Artery Disease Patients on Statin Treatment
Published: December 1, 2019 | DOI: https://doi.org/10.7860/JCDR/2019/42447.13388
Sumina Cheriyan, Deepti Girija Nandakumaran, D Dinesh Roy, Jaideep Mahendra, Viji Krishnan
1. Research Scholar, Department of Biochemistry, Meenakshi University, Chennai, Tamil Nadu, India.
2. Associate Professor, Department of Biochemistry, Believers Church Medical College, Tiruvalla, Kerala, India.
3. Director, Genitika, Center for Advanced Genetic Studies, Trivandrum, Kerala, India.
4. Associate Professor, Department of Prosthodontics, Meenakshi ammal Dental College, Chennai, Tamil Nadu, India.
5. Associate Professor, Department of Biochemistry, Jubilee Mission Medical College, Thrissur, Kerala, India.
Correspondence
Dr. Deepti Girija Nandakumaran,
Associate Professor, Department of Biochemistry, Believers Church Medical College Hospital, Thiruvalla-689103, Kerala, India.
E-mail: dgn_3@yahoo.co.in
Introduction: Oxidised Low Density Lipoprotein Cholesterol (Ox-LDL-C) and High Density Lipoprotein Cholesterol (HDL-C) have antagonistic action in the development of atherosclerotic cardiovascular disease. Use of statins reduces cardiovascular risk by reducing LDL-C levels and also by increasing HDL-C. No systematic studies were carried out to study the role of HDL-C as an antioxidant and its effect in decreasing Ox-LDL-C.
Aim: To compare the values of Ox-LDL-C/HDL-C in patients with chronic Coronary Artery Disease (CAD) and patients with Acute Coronary Syndrome (ACS) and to evaluate the levels of Ox-LDL-C and Ox LDL-C/HDL-C ratio in patients treated with the two different statins.
Materials and Methods: In this cross-sectional study 30 patients with ACS and 30 patients with chronic CAD on rosuvastatin or atorvastatin were included in the study. Apparently normal 27 age and sex-matched controls without CAD was included in the study. Lipid profile was estimated using fully auto analyser and Ox-LDL-C was estimated using ELISA kits. Statistical analysis was done using SPSS version 16 software. A p-value of <0.05 was considered as statistically significant.
Results: Hypertension and diabetes were found to be significantly associated with CAD (p-value 0.03). There was significant correlation between total cholesterol, triglycerides, with CAD. The levels of triglycerides, Ox-LDL-C and Ox-LDL-C/HDL-C were significantly higher (p<0.05) in ACS patients compared to chronic CAD and normal. Total cholesterol and LDL-C were lower in chronic CAD patients on atorvastatin treatment compared to patients on rosuvastatin treatment.
Conclusion: Ox-LDL-C/HDL-C ratio is a better predictor of acute coronary events. In addition to lipid lowering action, statins have pleiotropic benefits including prevention of LDL oxidation.
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